THe SCIENCE 

CBD research is rapidly increasing, including studies from The National Health Institute and mutiple universities. 

An experiment by Paul F. Consroe was performed where CBD was tested as a treatment for epilepsy. Patients stayed on the anticonvulsants, which were not causing any relief in symptoms. 200 mg/day of CBD or a placebo was added to the experiment. Consroe noted that of the seven patients getting CBD; three became seizure-free; one experienced only one or two seizures; and two experienced reduced severity and occurrence of seizures. Only one showed no improvement. Earlier this year Brazil approved the use of CBD to treat epilepsy

Cannabinoids help preserve brain matter in stroke, seizures, and traumatic brain injury. Studies have shown that cannabidiol (CBD) at a concentration of 10 uM is a neuroprotective against glutamate and oxidant hydroperoxide induced neurotoxicity.

CBD has been shown in both tissue studies in mice to be effective at inhibiting the growth of many cancers. CBD antioxidants have been shown to decrease the incidence of cancer. There are several mechanisms for this anti-cancer effect: CBD affects a gene, which controls metastasis and encourages apoptosis (natural death of old or abnormal cells). Scientists associated with the International Cannabinoid Research Society have identified a number of molecular pathways through which CBD exerts a therapeutic impact. A study by Dr. Sean McAllister at the California Pacific Medical Center reported on how CBD destroys breast cancer cells by regulating a gene called ID-1, which is implicated in several types of cancer. Silencing the ID-1 gene is; a potential strategy for cancer treatment, using CBD as a proposed treatment. 

Jose Alexandre Crippa at the University of San Paulo conducted research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the 5-HT1A hydroxytryptamine serotonin receptor, thereby conferring an anti-anxiety effect. This G-coupled protein receptor is implicated in anxiety, addiction, and appetite, sleep disruption, pain perception, nausea and vomiting.

CBD directly interacts with ion channels to confer a therapeutic effect. CBD binds to TRPV1 receptors, which also function as ion channels. TRPV1 is known to mediate pain perception, inflammation and body temperature. Therefore, CBD helps regulate pain and inflammation. 

Cannabidiol activates the 5-HT1A-serotonin receptor, some studies indicate that CBD functions as an antagonist that blocks, or deactivates another G protein-coupled receptor known as GPR55. It is involved in regulating blood pressure and bone density. GPR55 promotes cancer cell proliferation, according to a 2010 study by researchers at the Chinese Academy of Sciences. This receptor is expressed in various types of cancer. CBD also exerts an anti-cancer effect by activating PPARs peroxisome proliferator activated receptors that are situated on the surface of the cell’s nucleus. Activating these receptors induce tumor regression in human lung cancer cell lines and the development of Alzheimer’s disease. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful remedy for Alzheimer’s patients.

CBD calms and detoxes the nervous system. Scientific studies are showing positive results between the correlation between calming the nervous system and CBD oil in preventing and reducing disease.